Overview
The complete genome sequence of the tuberculosis bacterium was published in 1998. Following this initial sequencing, scientists have engaged in efforts to decipher the functions of the bacterium's genes. Approximately two-thirds of these genes have been characterized since the genome's initial publication.
Research Context
The foundational work for understanding the tuberculosis bacterium involved the sequencing of its complete genome, which concluded and was published in 1998. This milestone provided a comprehensive genetic blueprint for the organism. Subsequently, scientific endeavors have focused on elucidating the specific roles and functions of the genes within this genome. Despite these efforts, a portion of the genome, specifically about one-third, remains undeciphered regarding its gene functions.
Findings
The primary observation is that while the tuberculosis bacterium's genome was fully sequenced in 1998, the understanding of its genes is not yet complete. Approximately two-thirds of the bacterium's genes have had their functions deciphered. This leaves about one-third of the genes whose roles are not yet understood.
Why This Matters
The continued deciphering of the tuberculosis bacterium's genes, even decades after its genome sequencing, indicates an ongoing effort to understand the pathogen's biology. The revelation that not all 'known' genes have fully understood biological roles suggests potential for new discoveries regarding the bacterium's mechanisms, particularly under stress.